Z. Yan

Rapid protein evolution by few-shot learning with a protein language model

This paper introduces EVOLVEpro, a few-shot learning framework using protein language models to rapidly improve protein activity with minimal experimental data.

MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi

This study identifies MCP5 as essential for Borrelia burgdorferi's immune evasion and transmission, regulated by two signaling pathways.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Evolutionary analysis of paired box gene family and biological function exploration of Lr.Pax7 in lamprey (Lethenteron reissneri)

This study identifies and analyzes Pax7 in lamprey, showing its potential ancestral role and functional similarities to higher vertebrates in metabolic and developmental processes.

PLK1-Mediated Phosphorylation Cascade Activates the Mis18 Complex to Ensure Centromere Inheritance

The paper identifies PLK1-mediated phosphorylation of Mis18 and Mis18BP1 as essential for activating the Mis18 complex to ensure CENP-A loading and centromere inheritance.

Nodulation Trio in Medicago truncatula: Unveiling the Overlapping Roles of MtLYK2, MtLYK3, and MtLYK2bis

This study investigates the roles of MtLYK2, MtLYK3, and MtLYK2bis in Medicago truncatula nodulation using CRISPR/Cas mutants, finding redundant functions and suggesting a one-receptor model with multiple specificities.

Armillaria korhonenii, the sixteenth biological species of Armillaria from China

The paper describes a new species of Armillaria, Armillaria korhonenii, based on phylogenetic, morphological, and mating test evidence, identifying it as the sixteenth biological species in China.

Identification of Host Restriction Factors Critical for Recombinant AAV Transduction of Polarized Human Airway Epithelium

This study identifies host restriction factors critical for rAAV2.5T transduction of polarized human airway epithelium, revealing KIAA0319L's role in transduction but not internalization, and WDR63's role in transduction without involvement in internalization or nuclear entry.

Novel Epidermal Oxysterols Function as Alarm Substances in Zebrafish

This study identifies two novel oxysterol sulfates in zebrafish skin that function as alarm substances, inducing anti-predator behaviors and increasing cortisol levels at sub-nanomolar concentrations.

LUZP1 regulates the assembly of stress fibers by promoting maturation of contractile actomyosin bundles

This study identifies LUZP1 as a regulator of actomyosin bundle assembly, showing its role in myosin II filament concatenation and stress fiber formation.

RFC1 AAGGG pentanucleotide repeats form parallel G-quadruplex: structural implications for aberrant molecular cascades in CANVAS

The paper identifies and structures the G-quadruplex formed by RFC1 AAGGG repeats, showing its role in replication stalling and transcription inhibition in CANVAS.

Butyrate Protects against SARS-CoV-2-induced Tissue Damage in Golden Hamsters.

This study shows butyrate protects against SARS-CoV-2-induced tissue damage in golden hamsters by enhancing antiviral immunity and reducing oxidative stress.

Use of Artificial Intelligence for Automated Detection and Surveillance of Red Imported Fire Ants Nests

This study develops an AI system using robotic dogs to detect red imported fire ant nests with 95% precision, improving surveillance and pesticide delivery in open fields.

A parasitoid serpin gene that disrupts host immunity shows adaptive evolution of alternative splicing

The paper studies the evolution of alternative splicing and gene duplication in a parasitoid serpin gene, finding they jointly contribute to protein diversity and show divergent evolutionary patterns.

The genomic landscape of swine influenza A viruses in Southeast Asia

This study analyzes the genomic diversity of swine influenza A viruses in Southeast Asia, identifying novel variants and highlighting the need for improved surveillance.

Comparing Inference under the MSC versus the MSC-with-Recombination

This study compares three methods for estimating population parameters under different coalescent models, showing that diCal2 performs worse despite being designed for recombination.

"Correcting'' gene trees to be more like species trees increases topological error when incomplete lineage sorting is high

This paper shows that gene tree correction methods can increase topological error when incomplete lineage sorting is high, suggesting that correction should consider the species phylogeny.

Integrated single-nucleus and spatial transcriptomics captures transitional states in soybean nodule symbiosis establishment

The paper integrates single-nucleus and spatial transcriptomics to map transitional states in soybean nodule symbiosis, identifying functionally distinct cell subgroups and a transitional infected cell subtype.

Fatty acid binding protein 1 and fatty acid synthetase overexpression have differential effects on collagen III and cross-linking in Zongdihua pig tissues

This study investigates the effects of FABP1 and FAS overexpression on collagen III and cross-linking in Zongdihua pig tissues, identifying their roles in fat deposition.

ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression

This study identifies ST6GAL1 sialyltransferase as a promoter of acinar-to-ductal metaplasia and pancreatic cancer progression through glycosylation-dependent mechanisms.

Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy

This study shows SARS-CoV-2 Spike protein causes abnormal blood clots and thromboinflammation, which are neutralized by a fibrin-targeting antibody.

Nanocrown electrodes for reliable and robust intracellular recording of cardiomyocytes and cardiotoxicity screening

This paper develops nanocrown electrodes for reliable intracellular recording of cardiomyocytes and demonstrates their use in cardiotoxicity screening.

Spike independent infection of human coronavirus 229E in bat cells

This study shows that human coronavirus 229E can infect bat cells without using its spike protein, revealing a spike-independent infection mechanism in bats.

SGLT2 inhibitors therapy protects glucotoxicity-induced β-cell failure in a mouse model of human KATP-induced diabetes trough mitigation of oxidative and ER stress

This study shows SGLT2 inhibitors reduce oxidative and ER stress, restoring β-cell function in early-stage NDM mice but not when β-cell mass and identity are already lost.

Structure-based screening of drug candidates targeting the SARS-CoV-2 envelope protein

This study identifies two E protein inhibitors for SARS-CoV-2 using structural modeling and virtual screening, including a compound in clinical trials.

Cryo-EM structures of human TMEM120A and TMEM120B

The paper reports cryo-EM structures of human TMEM120A and TMEM120B, revealing similar dimeric assemblies but no structural basis for their differing mechanosensing properties.

Species Tree Inference on Data with Paralogs is Accurate Using Methods Intended to Deal with Incomplete Lineage Sorting

This study shows that species tree inference methods can accurately handle data with paralogs, even when incomplete lineage sorting is present.

Heat wave event facilitates defensive responses in invasive C3 plant Ambrosia artemisiifolia L. under elevated CO2 concentration to the detriment of insect herbivores

The paper examines how heat waves and elevated CO2 affect Ambrosia artemisiifolia growth, secondary metabolism, and its impact on leaf beetles, showing enhanced plant defenses and reduced herbivore performance.

Endothelial alpha globin is a nitrite reductase

This study shows endothelial alpha globin functions as a nitrite reductase to mediate hypoxia-induced vasodilation in resistance arteries.