Heme oxygenase-1 deficiency affects bone marrow niche and triggers premature exhaustion of hematopoietic stem cells.
K. Szade, M. Zukowska, A. Szade, W. N. Nowak, M. Ciesla, K. Bukowska-Strakova, G. S. Gulati, N. Kachamakova-Trojanowska, A. Kusienicka, E. Einwallner, J. Kijowski, S. Czauderna, H. Esterbauer, I. L. Weissman, J. Dulak, A. Jozkowicz
This study shows that HO-1 deficiency in the bone marrow niche leads to premature HSC exhaustion and aging features, which can be reversed by transplanting HO-1-expressing HSCs.
bioRxiv · Dec 10, 2018Cell Biology