Cell BiologybioRxiv
Heme oxygenase-1 deficiency affects bone marrow niche and triggers premature exhaustion of hematopoietic stem cells.
K. Szade, M. Zukowska, A. Szade…·A. Jozkowicz
This study shows that HO-1 deficiency in the bone marrow niche leads to premature HSC exhaustion and aging features, which can be reversed by transplanting HO-1-expressing HSCs.
DOI 10.15252/embr.201947895