Targeting Apollo-NADP+ to image NADPH generation in pancreatic beta-cell organelles
H. H. Chang, A. M. Bennett, W. D. Cameron, E. Floro, A. Au, C. M. McFaul, C. M. Yip, J. V. Rocheleau
The paper develops organelle-targeted Apollo-NADP+ sensors to study glucose- and glutamine-stimulated NADPH production in pancreatic beta-cell organelles, revealing mitochondria's key role in NADPH generation.
bioRxiv · Apr 27, 2022Cell Biology