N. Jiang

Dearth of smoking-induced mutations in NSRO-driven non-small-cell lung cancer despite smoking exposure

The paper examines genomic and transcriptomic changes in NSRO-driven NSCLCs in smokers and non-smokers, finding no smoking-induced mutations but higher transcriptomic cell cycle activity in smokers.

Bivalent mRNA vaccine improves antibody-mediated neutralization of many SARS-CoV-2 Omicron lineage variants

This study evaluates the neutralizing antibody response to bivalent mRNA vaccines against multiple Omicron variants, showing enhanced neutralization against BQ.1 and BQ.1.1.

Tumor microenvironments impair T cell receptor affinity and function

This study shows that CD8+ T cells in the tumor microenvironment have reduced TCR-pMHC affinity and function, impairing their anti-tumor activity.

Increased ozone levels disrupt insect sexual communication

This study shows that increased ozone levels oxidize male-specific pheromones in Drosophila melanogaster, reducing pheromone amounts and altering sexual recognition.

Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii

This study maps lactylation sites in Toxoplasma gondii and identifies its role in gene regulation and metabolic processes.

Analysis and Identification of Necroptosis Landscape on Therapy and Prognosis in Bladder Cancer

This study identifies a necroptosis-related gene signature (NRGscore) to predict prognosis and therapeutic response in bladder cancer patients using TCGA data.

Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

This study evaluates how well antibodies from mRNA vaccines neutralize SARS-CoV-2 variants, finding that Omicron shows the most escape but booster doses maintain moderate neutralizing activity.

TopoRoot: A method for computing hierarchy and fine-grained traits of maize roots from X-ray CT images

TopoRoot computes fine-grained root traits from maize root CT images, improving accuracy over existing methods and enabling automated analysis of root system architecture.

High-Throughput and High-Dimensional Single Cell Analysis of Antigen-Specific CD8+ T cells

This study introduces TetTCR-SeqHD, a method to profile antigen-specific CD8+ T cells, revealing unique phenotypes and cross-reactive TCRs in type 1 diabetes.

Complementary Phenotyping of Maize Root Architecture by Root Pulling Force and X-Ray Computed Tomography

This study combines X-ray computed tomography and root pulling force measurements to improve 3D root system architecture analysis in maize.

Femtosecond laser microdissection isolating regenerating C. elegans neurons for single cell RNA sequencing

This study introduces femtosecond laser microdissection (fs-LM) to isolate regenerating C. elegans neurons for single-cell RNA sequencing, revealing gene modules linked to axon regrowth rates.

SARS-CoV-2 susceptibility of cell lines and substrates commonly used in diagnosis and isolation of influenza and other viruses

This study evaluates SARS-CoV-2 susceptibility in cell lines used for influenza and other virus diagnosis, finding that some are permissive while others are not, with MDCK cells being insusceptible due to low ACE2 expression.

X-ray microscopy enables multiscale high-resolution 3D imaging of plant cells, tissues, and organs

This paper introduces a lab-based X-ray microscope for multiscale 3D imaging of plant structures, enabling detailed analysis from the cellular to whole-plant level.

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility

This study shows the SARS-CoV-2 D614G variant has enhanced replication and transmissibility in animal models, explaining its global dominance.

An Antioxidant Enzyme Therapeutic for COVID-19

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

Flocked swab might be one main reason causing the high false-negative rate in COVID-19 screening----the advantages of a novel silicone swab

The paper compares silicone and cotton swabs for RNA extraction in COVID-19 testing, finding silicone swabs yield higher RNA concentration and quality.

Characterization of xyloglucan-specific fucosyltransferase activity in Golgi-enriched microsomal preparations from wheat seedlings

This paper investigates XyG biosynthesis in wheat seedlings and shows that wheat fucosyltransferase activity can fucosylate tamarind XyG in vitro, suggesting conserved XyG fucosylation mechanisms between monocots and dicots.

Characterizing grapevine (Vitis spp.) inflorescence architecture using X-ray imaging: implications for understanding cluster density

The paper uses X-ray imaging and computational methods to analyze grapevine inflorescence architecture across species, identifying traits linked to cluster density and phylogenetic patterns.

Mapping the lineage relationship between CXCR5+ and CXCR5- CD4+ T cells in HIV infected human lymph nodes

The paper identifies a CXCR5-negative CD4+ T cell subset in HIV-infected lymph nodes that shares lineage and functional traits with CXCR5+ T follicular helper cells.

Probing cellular response to topography in three dimensions

This study investigates how cells respond to 3D topographical cues in engineered matrices, finding that myosin II regulates protrusion orientation in response to aligned fibers.

High-throughput determination of the antigen specificities of T cell receptors in single cells

This paper introduces TetTCR-Seq to link TCR sequences to their antigens in single cells and identifies neo-antigen-specific TCRs with no cross-reactivity.

High-resolution 4D spatiotemporal analysis reveals the contributions of local growth dynamics to contrasting maize root architectures

The paper uses high-resolution 4D imaging to analyze maize root growth dynamics and shows how local growth patterns determine contrasting root architectures across genotypes.

Accurate Immune Repertoire Sequencing Reveals Malaria Infection Driven Antibody Lineage Diversification in Young Children

The paper introduces a high-coverage antibody repertoire sequencing method, MIDCIRS, and uses it to show increased somatic hypermutation in infants and toddlers during malaria infection.