SIRPα controls CD47-dependent platelet clearance in mice and humans
M. Shoham, Y. Y. Yiu, P. Hansen, A. Subramaniam, M. Broberg, E. Gars, T. Raveh, FinnGen, I. L. Weissman, N. Sinnott-Armstrong, A. Krishnan, H. Ollila, M. C. Tal
This study shows that the CD47-SIRP axis regulates platelet homeostasis and that blocking this interaction affects platelet levels in mice and humans.
bioRxiv · Dec 9, 2023 · PreprintImmunology