A. Krishnan

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.

Evolutionary Dynamics of Lineage-Specific Class-A GPCR Subsets Reveal Widespread Chemosensory Roles and Adaptations in Lophotrochozoa

The paper identifies lineage-specific expansions of Class-A GPCRs in Lophotrochozoa, linking them to habitat adaptations and chemosensory functions.

Harmonising distributed tree inventory datasets across India can fill critical gaps in tropical ecology

The paper compiles and analyzes Indian tree inventory data to highlight sampling gaps and promote data standardization for tropical ecology studies.

Contrasting morphological and acoustic trait spaces suggest distinct benefits to participants in mixed-species bird flocks

The paper examines the relationship between morphological and acoustic traits in mixed-species bird flocks, finding that species are more similar in body mass than expected but not in acoustic traits.

IFNgamma-dependent remodelling of the myeloid landscape underlies control of IFNgamma-insensitive tumours

The paper shows that IFN-gamma-insensitive tumours can still be controlled by immune responses, with IFN-gamma driving myeloid cell remodelling that enhances anti-tumour immunity.

Prioritizing Maize Metabolic Gene Regulators through Multi-Omic Network Integration

This paper develops a framework to prioritize maize metabolic gene regulators by integrating multi-omic data, identifying over 3,000 TFs and predicting new regulators of hormone, developmental, and metabolic processes.

Individual-specific associations between behavioral events and song notes shape budgerigar vocal sequences

The paper examines individual-specific associations between behavioral events and song notes in budgerigars, finding both unique and universal patterns in their vocal sequences.

Effects of sampling methodology on phenology indices: insights from sites across India and modelling

This study examines how sampling methods affect phenology indices in tropical trees across India and provides recommendations for future research.

SIRPα controls CD47-dependent platelet clearance in mice and humans

This study shows that the CD47-SIRP axis regulates platelet homeostasis and that blocking this interaction affects platelet levels in mice and humans.

Platelet proteo-transcriptomic profiling validates mediators of thrombosis and proteostasis in patients with myeloproliferative neoplasms

The paper profiles the platelet proteome in MPN patients to identify mediators of thrombosis and proteostasis, validating key transcriptome findings.

Allopatric montane wren-babblers exhibit similar song notes but divergent vocal sequences

The paper quantitatively analyzes song syntax divergence in montane wren-babblers, finding similar notes but divergent syntactic structures across geographic regions.

Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia

This paper develops a T cell engager that uses IFNγ to upregulate CD38 on leukemia stem cells, enabling their targeting and depletion in AML.

Personalized transcranial alternating current stimulation improves sleep quality: Initial Findings

This study shows that personalized transcranial alternating current stimulation (tACS) improves sleep duration and reduces sleep onset latency compared to fixed-frequency tACS and a control condition.

Enkurin: A novel marker for myeloproliferative neoplasms from platelet, megakaryocyte, and whole blood specimens.

The paper identifies enkurin as a novel marker of myeloproliferative neoplasms (MPNs) through analysis of platelet, megakaryocyte, and whole blood specimens, showing inverse association with CDC20 and involvement of calcium homeostasis and ER stress.

Bill shape imposes biomechanical tradeoffs in cavity-excavating birds

This study examines biomechanical tradeoffs in bill shapes of cavity-excavating birds, finding that deeper and wider bills resist impact better but perform worse under torsion.

Climate influences bill shape diversification in cavity-excavating birds

This study examines how climate influences bill shape diversification in cavity-excavating birds, finding that maxillary shape correlates with climate variables and shows allometric scaling.

Higher-order dialectic variation and syntactic convergence in the complex warble song of budgerigars

This study examines vocal sequence variation in budgerigars and finds that colony-specific syntactic structures change upon social group contact, leading to convergence in vocal patterns.

The topological shape of gene expression across the evolution of flowering plants

This paper uses topological data analysis to create a topological representation of gene expression across flowering plants, revealing conserved expression patterns linked to tissues and stress responses.

Chlamydomonas Mutants Null for Chloroplast Triose Phosphate Transporter3 are Metabolically Compromised and Light Sensitive

This study identifies CreTPT3 as a critical chloroplast transporter in Chlamydomonas, showing its role in metabolite transport, oxidative stress prevention, and subfunctionalization with CreTPT2.

Modeling clonal evolution and oncogenic dependency in vivo in the context of hematopoietic transformation

This study models clonal evolution and oncogenic dependency in hematopoietic transformation using reversible mutagenesis and allelic frameworks.

CXCL8/CXCR2 signaling mediates bone marrow fibrosis and represents a therapeutic target in myelofibrosis

This study identifies CXCL8/CXCR2 signaling as a driver of bone marrow fibrosis in myelofibrosis and shows its therapeutic potential through genetic and pharmacologic inhibition.

Seasonality and interspecific temporal partitioning in a semiarid grassland bat assemblage

The paper examines seasonal and interspecific temporal partitioning in a semiarid grassland bat assemblage, showing species-specific activity patterns and competition avoidance at water bodies.

Toxoplasma gondii phosphatidylserine flippase complex ATP2B-CDC50.4 critically participates in microneme exocytosis

This study identifies the ATP2B-CDC50.4 complex as critical for phosphatidylserine flipping and microneme exocytosis in Toxoplasma gondii.

Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii

This study shows that pantothenate biosynthesis is critical for chronic Toxoplasma gondii infection, while CoA synthesis is essential for acute stages.

Patterns of morphological diversification in the Ramphastoidea reveal the dramatic divergence of toucans from a conserved morphotype

The paper analyzes morphological diversification in toucans and barbets across three continents, finding a conserved morphotype with toucans diverging into a distinct trait space.

Revisiting the role of Toxoplasma gondii ERK7 in the maintenance and stability of the apical complex

This paper shows that Toxoplasma gondii ERK7 depletion mimics AC9/AC10 depletion, causing apical complex disorganization and impairing parasite motility and invasion.

Behavioral context shapes vocal sequences in two anuran species with different repertoire sizes

This study examines how two frog species adjust their vocal sequences based on behavioral context, showing context-dependent modifications in vocal repertoires despite differences in repertoire size.

Ecological specialisation and evolutionary reticulation in extant Hyaenidae

This study generates an aardwolf genome and analyzes it with other hyena genomes to explore evolutionary relationships, dietary adaptations, and genetic diversity patterns in Hyaenidae.

Convergent acoustic community structure in South Asian dry and wet grassland birds

The paper examines acoustic community structure in South Asian dry and wet grasslands, finding convergent signal space despite differences in phylogenetic diversity.

True S-cones are concentrated in the ventral mouse retina for color detection in the upper visual field

The paper identifies a high concentration of true S-cones in the ventral mouse retina, suggesting an adaptation for enhanced color detection in the upper visual field.