Development of an Accelerated Cellular Model for Alzheimer's Disease
H. Xue, S. J. Gates, E. Gentry, W. Losert, K. Cao
This study uses progerin to accelerate AD phenotypes in neural progenitor cells with FAD mutations, showing increased tau phosphorylation, amyloid plaques, and cell death within weeks.
bioRxiv · May 9, 2023Cell Biology