W. Losert

Astrocytes are active: An information theoretic approach reveals differences in Ca2+ signaling patterns among distinct astrocyte subtypes

This paper uses an information-theoretic approach to analyze Ca2+ signaling differences among astrocyte subtypes and finds distinct responses to perturbations.

Development of an Accelerated Cellular Model for Alzheimer's Disease

This study uses progerin to accelerate AD phenotypes in neural progenitor cells with FAD mutations, showing increased tau phosphorylation, amyloid plaques, and cell death within weeks.

Coupled Biomechanical and Ionic Excitability in Developing Neural Cell Networks

The paper measures biomechanical dynamics of actin polymerization in neural precursor cells and shows its impact on ionic dynamics and cell-cell coupling during differentiation.

Propagation dynamics of electrotactic motility in large epithelial cell sheets

The paper uses electric fields to induce migration in human keratinocyte sheets and develops an in silico model showing how directional cues propagate to drive coherent collective migration.

Nanotopography modulates intracellular excitable systems through cytoskeleton actuation

The paper shows nanotopography is sensed directly by cytoskeletal networks, with implications for texture sensing and guidance cues in microenvironments.

Label-free Cell Tracking Enables Collective Motion Phenotyping in Epithelial Monolayers

The paper introduces an AI-based pipeline to track cell nuclei in phase contrast images and uses it to analyze collective motion in epithelial monolayers, finding that D2min correlates with metastatic potential.

Cortical waves mediate the cellular response to electric fields

The paper shows electric fields guide cell movement by controlling biochemical waves and cytoskeletal activity, with faster response on nanotopographic surfaces.

Spontaneous polarization and cell guidance on asymmetric nanotopography

This study models cell migration on asymmetric nanosawteeth, showing that actin polymerization rate and sawtooth dimensions influence directional bias and motion phenotypes.

Actin dynamics as a multiscale integrator of cellular guidance cues

This paper shows how actin polymerization dynamics integrate subcellular and cellular-scale guidance cues to direct cell migration.

Signaling through polymerization and degradation: Analysis and simulations of T cell activation mediated by Bcl10

This paper quantifies Bcl10 filament dynamics in T cell activation using microscopy and simulations, showing degradation at filament ends controls response timing.

Distinct Roles of Tumor-Associated Mutations in Collective Cell Migration

The paper investigates how tumor-associated mutations affect collective cell migration, finding that PTEN deletion enhances it while Ras activation suppresses it, with implications for metastasis.

The social shape of sperm: Using an integrative machine-learning approach to examine sperm ultrastructure and collective motility

The paper uses machine learning to analyze sperm morphology and collective motility in Peromyscus mice, finding that head elongation correlates with aggregation behavior.

Quantifying topography-guided actin dynamics across scales using optical flow

The paper quantifies actin wave dynamics on periodic topographies using optical flow, finding similar nanotopography-guided actin behavior in two cell types despite differences in wave speed and morphology.