S. H. Lee

The paper identifies modular organization in human superior temporal gyrus for phoneme processing using high-density micro-arrays.

This study uses spatial transcriptomics to analyze gastric cancer tumor microenvironments, identifying subtypes and functional interactions between cell types that correlate with clinical outcomes.

This study identifies CYP3 subfamily gene variants and differential expression of detoxification enzymes as key factors in deltamethrin resistance in Helicoverpa armigera, rather than target site mutations.

This study identifies electrostatic interactions between hyperphosphorylated tau and polyamines as crucial for tau aggregation in Alzheimer's disease and observes the transition from aggregates to fibrils.

The paper introduces an in vitro assay to study hyphal constriction in Magnaporthe oryzae, identifying transcriptional changes and a potential histone modification role in this process.

This study engineers IsPETase to balance PET hydrolysis activity and thermostability, resulting in a variant that outperforms existing variants in depolymerization efficiency.

The paper identifies a novel imidazolium antibiotic from Bacillus licheniformis and proposes its biosynthetic pathway through various experimental methods.

The paper shows that epidermis-derived lactate promotes sterile inflammation by inducing metabolic changes in macrophages that support their effector functions.

This study identifies C5aR1 signaling in sensory neuron-associated macrophages as a driver of neuropathic pain and shows it can be inhibited to reduce pain.

This paper introduces multi-pass flow cytometry using laser particle barcoding to enable high-dimensional single-cell analysis with reduced spectral overlap and simplified panel design.

The paper identifies actin filaments and dynamin as key forces mediating non-coated membrane budding in live cells, revealing mechanisms that transform flat membranes into vesicles.

This study shows that murine VL30 retrotransposons can be inadvertently transferred to CAR-T cells via γ-retroviral vectors, raising biosafety concerns.

This study shows that EFHD1 deletion reduces mitochondrial Ca2+ overload and ROS production, protecting cardiomyocytes from ischemia-induced injury.

The paper enhances CRISPR-Cas12a system specificity and efficiency using a chimeric DNA-RNA guide, achieving 7.41 and 7.60 times improvements respectively.

This study identifies Tert+ acinar cells as critical for pancreatic regeneration, showing their activation by Yap/Taz and their role in tissue repair.

This study tests virtual prism adaptation therapy using a depth-sensing camera and fNIRS in healthy adults to assess behavioral and cortical changes during adaptation phases.

This paper introduces a high-content, high-throughput phenotypic assay for studying the erythrocytic cycle of malaria parasites with hourly resolution.

This study identifies sex-specific bile acid metabolism differences that protect female livers from liver cancer and suggests targeting bile acid excretion as a therapeutic strategy.

This study investigates how dermis resident macrophages and neutrophils interact during early Leishmania major infection transmitted by sand fly bite, revealing the role of phagocytosis and receptor tyrosine kinases in infection outcomes.

The paper reviews 419 studies on mutualistic networks and argues that core-periphery structure is more relevant than nestedness for describing ecological network topology, providing code for its calculation in R.

This study evaluates agmatine's protective effect against cisplatin-induced apoptosis in HEI-OC1 auditory cells, showing reduced BAX and caspase-3 activity.

This study enhances CRISPR-Cas12a specificity by using a chimeric DNA-RNA guide, reducing off-target mutations in genome editing.

This paper demonstrates the feasibility of using PET imaging to track 89Zr-DFO-labeled CAR T-cells in vivo, showing their distribution and migration over time.

This paper identifies PNGM-1, a dual-activity enzyme with metallo-β-lactamase and tRNase Z functions, and shows it evolved from tRNase Z, providing insights into the origin of subclass B3 metallo-β-lactamases.

The paper surveys Borrelia species in Irish Ixodes ricinus ticks using 16S rRNA gene sequencing to identify infection rates and species diversity.

This study uses smFRET to show Cas9 searches for PAM sequences via one-dimensional diffusion, competing with 3D diffusion for efficient target binding.

The paper reports cancer-associated transcript fusions in 33 tumor types using TCGA data and provides a resource for accessing the results.