Mitochondrial proteostasis mediated by CRL5Ozz and Alix maintains skeletal muscle function
Y. Campos, R. Rodriguez-Enriquez, G. Palacios, D. Van de Vlekkert, X. Qiu, J. Weesner, E. Gomero, J. Demmers, T. Bertorini, J. T. Opferman, G. T. Grosveld, A. d'Azzo
This study identifies CRL5Ozz and Alix as regulators of mitochondrial proteostasis by controlling Slc25A4 levels, which impacts mitochondrial function and muscle fiber composition.
bioRxiv · Jul 11, 2023 · PreprintCell Biology