Author

J. T. Opferman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

M. E. Turnis· 2 shared R. Rodriguez-Enriquez· 2 shared A. Budhraja· 1 shared A. d'Azzo· 1 shared C. Mullighan· 1 shared D. Van de Vlekkert· 1 shared E. Gomero· 1 shared G. Palacios· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPhysiology

M. E. Turnis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Inducible genetic ablation of Immt induces a lethal disruption of the MICOS complex

S. M. Rockfield, M. E. Turnis, R. Rodriguez-Enriquez, M. Bathina, S. K. Ng, S. Pelletier, P. Vogel, J. T. Opferman

This study shows that deleting Immt, which encodes MIC60, in mice causes lethal disruption of the MICOS complex, leading to intestinal defects and bone marrow issues.

bioRxiv · Aug 22, 2023 · PreprintPhysiology

Mitochondrial proteostasis mediated by CRL5Ozz and Alix maintains skeletal muscle function

Y. Campos, R. Rodriguez-Enriquez, G. Palacios, D. Van de Vlekkert, X. Qiu, J. Weesner, E. Gomero, J. Demmers, T. Bertorini, J. T. Opferman, G. T. Grosveld, A. d'Azzo

This study identifies CRL5Ozz and Alix as regulators of mitochondrial proteostasis by controlling Slc25A4 levels, which impacts mitochondrial function and muscle fiber composition.

bioRxiv · Jul 11, 2023 · PreprintCell Biology

Heme-Sensing Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics

K. H. Smith, A. Budhraja, J. Lynch, K. Roberts, J. C. Panetta, J. P. Connelly, M. E. Turnis, S. M. Pruett-Miller, J. D. Schuetz, C. Mullighan, J. T. Opferman

The paper identifies the heme-sensing pathway as a regulator of MCL-1 expression in B-lineage acute leukemia, showing that modulating this pathway enhances sensitivity to BH3-mimetics.

bioRxiv · Apr 10, 2020Cancer Biology