Author

J.-p. Li

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2

Frequent Co-Authors

I. Vlodavsky· 2 shared L. Chen· 2 shared S.-Z. Luo· 2 shared A. Agelidis· 1 shared A. Campeau· 1 shared A. Hargil· 1 shared B. A. Falk· 1 shared B. A. Turturice· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

I. Vlodavsky

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Heparan sulfate dependent phase separation of CCL5 and its chemotactic activity

X. Yu, G. Duan, P. Pei, L. Chen, R. Gu, W. Hu, H. Zhang, Y.-D. Wang, L. Gong, L. Liu, T.-T. Chu, J.-P. Li, S.-Z. Luo

This study shows that CCL5 and heparan sulfate form phase-separated gradients, which guide immune cell migration, and demonstrates this through in vitro and in vivo experiments.

bioRxiv · Nov 15, 2023Cell Biology

FOXP3+ regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues

H. A. Martinez, I. Koliesnik, G. Kaber, N. Nagy, G. Barlow, B. A. Falk, J. K. Reid, C. O. Medina, A. Hargil, I. Vlodavsky, J.-p. Li, M. Perez-Cruz, S.-W. Tang, E. H. Meyer, L. E. Wrenshall, , H. F. Kuipers

The paper shows FOXP3+ Treg use heparanase to access IL-2 bound to ECM in inflamed tissues, enhancing their function and stability.

bioRxiv · Feb 26, 2023Immunology

Phase separation on cell surface: a mechanism of basic fibroblast growth factor signal transduction with heparan sulphate

S. Xue, F. Zhou, T. Zhao, H. Zhao, X. Wang, L. Chen, J.-p. Li, T. Tan, S.-Z. Luo

This study shows that basic fibroblast growth factor (bFGF) undergoes liquid-liquid phase separation on the cell surface with heparan sulphate proteoglycans (HSPG), which is essential for downstream signaling.

bioRxiv · May 24, 2021 · PreprintBiochemistry

STAT3 inhibits Myocardin induced cardiac hypertrophy

X.-H. Liao, Y. Xiang, J.-P. Li, H. Li, Y. Huang, C. Shen, Z. zhang, T.-C. Zhang

The paper identifies STAT3 as an inhibitor of Myocardin-mediated cardiac hypertrophy by directly binding to Myocardin and suppressing its transcriptional activity.

bioRxiv · Nov 21, 2020 · PreprintCell Biology

Rapid development of SARS-CoV-2 receptor binding domain-conjugated nanoparticle vaccine candidate

Y.-F. Kang, C. Sun, Z. Zhuang, R.-Y. Yuan, Q.-B. Zheng, P.-P. Zhou, J.-P. Li, X.-C. Chen, X. Zhang, X.-H. Yu, X.-W. Kong, Q.-Y. Zhu, M. Xu, N.-S. Zhong, Y.-X. Zeng, , M.-S. Zeng

This study designs and tests RBD-conjugated nanoparticle vaccines against SARS-CoV-2, showing enhanced neutralizing activity compared to monomeric RBD.

bioRxiv · Nov 3, 2020 · PreprintMicrobiology

Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival

A. Agelidis, B. A. Turturice, R. K. Suryawanshi, T. Yadavalli, D. Jaishankar, J. Ames, J. Hopkins, L. Koujah, C. D. Patil, S. R. Hadigal, E. J. Kyzar, A. Campeau, J. M. Wozniak, D. J. Gonzalez, I. Vlodavsky, , D. Shukla

This study shows that HPSE disrupts innate defense responses, promoting cell survival during HSV-1 infection by inhibiting cell-intrinsic defenses and facilitating host cell reprogramming.

bioRxiv · Aug 5, 2020Cell Biology