N. Nagy

Inhibition of hyaluronan synthesis prevents β-cell loss in obesity-associated type 2 diabetes

This study shows that inhibiting hyaluronan synthesis with 4-MU prevents β-cell loss in obesity-associated type 2 diabetes by increasing survivin expression and blocking apoptosis.

FOXP3+ regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues

The paper shows FOXP3+ Treg use heparanase to access IL-2 bound to ECM in inflamed tissues, enhancing their function and stability.

Remodeling of the Ribosomal Quality Control and Protein Translation by a Viral Ubiquitin Deconjugase

This paper identifies a viral ubiquitin deconjugase that modulates ribosomal stress responses and translation, enhancing viral production and contributing to EBV-related diseases.

The pharmacokinetics and pharmacodynamics of 4-methylumbelliferone and its glucuronide metabolite in mice

This paper investigates the pharmacokinetics and pharmacodynamics of 4-MU and its metabolite 4-MUG in mice, showing significant differences in exposure and bioavailability between administration routes.

Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise

This study shows that chronic endurance training in dogs increases arrhythmia susceptibility through electrophysiological and molecular changes.

TLR2 on CD4+ and CD8+ T cells promotes late control of Mycobacterium tuberculosis infection

This study shows that TLR2 on CD4+ and CD8+ T cells is important for late control of Mycobacterium tuberculosis infection, but not early control.

The Epstein-Barr virus ubiquitin deconjugase BPLF1 regulates the activity of Topoisomerase II during virus replication

This study identifies BPLF1 as a regulator of TOP2 activity during EBV replication by modulating ubiquitination, SUMOylation, and DNA-damage response.

Hyaluronan Synthesis Inhibition Impairs Antigen Presentation and Delays Transplantation Rejection

This study shows that inhibiting hyaluronan synthesis with 4MU impairs antigen presentation and delays transplant rejection in mice and human T-cell reactions.

Sustained Release of IL-2 Using an Injectable Hydrogel Prevents Autoimmune Diabetes

This paper develops an IL-2 hydrogel that prevents diabetes in NOD mice by sustained release and immune modulation.

Immune cells lacking Y chromosome have widespread dysregulation of autosomal genes

The paper examines immune cells with mosaic loss of the Y chromosome, finding widespread dysregulation of autosomal genes and linking this to immune dysfunction and disease.

Inter-Species Differences in the Response of Sinus Node Cellular Pacemaking to Changes of Extracellular Calcium

The paper investigates inter-species differences in sinus node pacemaking response to changes in extracellular calcium using computational models of mouse, rabbit, and human cells.