A. Hargil

Dosing and Delivery of Bacteriophage Therapy In a Murine Wound Infection Model

This study evaluates phage therapy dosing and delivery in a mouse wound infection model, finding topical high-dose repeated administration effective and developing a sustained-release hydrogel system.

Pf bacteriophages hinder sputum antibiotic diffusion via electrostatic binding

This study shows Pf phages and sputum polymers reduce antibiotic diffusion through electrostatic binding and liquid crystal formation in chronic Pseudomonas aeruginosa infections.

Rapid assessment of changes in phage bioactivity using dynamic light scattering

This paper uses Dynamic Light Scattering to assess phage bioactivity changes over time and optimize storage conditions for clinical phage applications.

Inhibition of hyaluronan synthesis prevents β-cell loss in obesity-associated type 2 diabetes

This study shows that inhibiting hyaluronan synthesis with 4-MU prevents β-cell loss in obesity-associated type 2 diabetes by increasing survivin expression and blocking apoptosis.

FOXP3+ regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues

The paper shows FOXP3+ Treg use heparanase to access IL-2 bound to ECM in inflamed tissues, enhancing their function and stability.

Pf Bacteriophage Inhibits Neutrophil Migration in the Lung

The paper shows that Pf4 phage inhibits neutrophil migration in the lung by reducing CXCL5 production during bacterial infection.

A filamentous phage triggers antiviral responses in cystic fibrosis basal airway epithelial cells

This study investigates how cystic fibrosis basal airway epithelial cells respond to the filamentous phage Pf4 and LPS, showing antiviral responses and altered immune signaling.

The pharmacokinetics and pharmacodynamics of 4-methylumbelliferone and its glucuronide metabolite in mice

This paper investigates the pharmacokinetics and pharmacodynamics of 4-MU and its metabolite 4-MUG in mice, showing significant differences in exposure and bioavailability between administration routes.

Hyaluronan Synthesis Inhibition Impairs Antigen Presentation and Delays Transplantation Rejection

This study shows that inhibiting hyaluronan synthesis with 4MU impairs antigen presentation and delays transplant rejection in mice and human T-cell reactions.

Filamentous Bacteriophage Delay Healing of Pseudomonas-Infected Wounds

This study shows filamentous bacteriophage delays wound healing in Pseudomonas aeruginosa infections by inhibiting keratinocyte migration, supported by a patient cohort study.