D. Merkler

Persistent virus-specific and clonally expanded antibody secreting cells respond to induced self antigen in the CNS

The paper identifies virus-specific, clonally expanded antibody-secreting cells in the CNS that persist and respond to induced self-antigen, with parallels in multiple sclerosis patients.

Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity

The paper profiles clonal selection of B and T cells in murine models of infection and autoimmunity using single-cell sequencing, linking repertoire features to cell phenotypes.

Brain endothelial antigen presentation detains CD8+ T cells at the blood-brain barrier leading to its breakdown

The paper shows that brain endothelial antigen presentation inhibits CD8+ T-cell movement and causes BBB breakdown in MS.

Clonally expanded virus-specific CD8 T cells acquire diverse transcriptional phenotypes during acute, chronic, and latent infections

This study examines clonal expansion and transcriptional diversity in virus-specific CD8 T cells across different infection stages using single-cell sequencing and a new bioinformatic tool.

Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming upon cold exposure

This study examines the tissue-specific transcriptional responses to cold exposure across multiple organs using RNA sequencing, revealing that gene expression changes are not driven by baseline expression patterns.

Progranulin promotes immune evasion of pancreatic adenocarcinoma through regulation of MHCI expression

This study shows that tumor-derived progranulin (PGRN) promotes immune evasion in pancreatic ductal adenocarcinoma by reducing MHC class I expression, and blocking PGRN enhances immune response and slows tumor progression.

Single-cell sequencing reveals clonally expanded plasma cells during chronic viral infection produce virus-specific and cross-reactive antibodies

Cold Exposure Protects from Neuroinflammation Through Immunologic Reprogramming

The paper shows cold exposure reduces neuroinflammation by altering monocyte function and T cell priming in mouse models of autoimmune encephalomyelitis.

Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice

This study uses single-cell sequencing to show that aged mouse brains have clonally expanded and transcriptionally distinct lymphocytes, potentially contributing to neuroinflammation.

Salivary gland macrophages assist tissue-resident CD8+ T cell immune surveillance

The paper uses imaging to show salivary gland TRM use unique motility and tissue macrophages assist in their surveillance.

Profound functional and molecular diversity of mitochondria revealed by cell type-specific profiling in vivo

The paper profiles mitochondrial proteomes in specific neural cell types to reveal functional and molecular diversity across cell types in mice and humans.

In vivo function of the lipid raft protein Flotillin 1 during CD8+ T cell-mediated host surveillance

This study investigates the role of Flotillin 1 in CD8+ T cell migration and immune responses, finding minimal impact on cell behavior under physiological conditions.