Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response via AP1 dichotomy in pancreatic cancer
L. Klein, M. Tu, N. Krebs, L. Urbach, D. G. Grimm, M. U. Latif, F. Penz, N. Chan, K. Aliar, F. Vyas, U. Kishore, E. Hessmann, A. Trumpp, E. Espinet, A. Papantonis, , S. K. Singh
The paper identifies AP1 transcription factor dichotomy and CD68+ macrophages as drivers of intratumoral subtype co-existence and therapy response in pancreatic cancer.
bioRxiv · Oct 30, 2023 · PreprintCancer Biology