Author

A. Papantonis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biophysics· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 8 Approach:experimental assay· 7 Organism:human· 7 Approach:statistical model· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:ChIP-seq· 3 Assay:DNA methylation· 3 Research Focus:gene regulatory network inference· 3

Frequent Co-Authors

N. Josipovic· 4 shared E. G. Gusmao· 3 shared A. Zirkel· 2 shared D. Marenduzzo· 2 shared D. Michieletto· 2 shared N. Crosetto· 2 shared P. R. Cook· 2 shared A. Angelopoulou· 1 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersCell Biology

N. Josipovic

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Increasingly efficient chromatin binding of cohesin and CTCF supports chromatin architecture formation during zebrafish embryogenesis

J. Cossmann, P. I. Kos, V. Varamogianni-Mamatsi, D. Assenheimer, T. Bischof, T. Kuhn, T. Vomhof, A. Papantonis, L. Giorgetti, J. C. M. Gebhardt

The paper investigates cohesin and CTCF chromatin binding dynamics during zebrafish embryogenesis, showing increased binding efficiency and its role in chromatin architecture formation.

bioRxiv · Dec 8, 2023Biophysics

Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response via AP1 dichotomy in pancreatic cancer

L. Klein, M. Tu, N. Krebs, L. Urbach, D. G. Grimm, M. U. Latif, F. Penz, N. Chan, K. Aliar, F. Vyas, U. Kishore, E. Hessmann, A. Trumpp, E. Espinet, A. Papantonis, , S. K. Singh

The paper identifies AP1 transcription factor dichotomy and CD68+ macrophages as drivers of intratumoral subtype co-existence and therapy response in pancreatic cancer.

bioRxiv · Oct 30, 2023 · PreprintCancer Biology

Competition between transcription and loop extrusion modulates promoter and enhancer dynamics

A. Platania, C. Erb, M. Barbieri, B. Molcrette, E. Grandgirard, M. A. de Kort, K. Meaburn, T. Taylor, V. M. Shchuka, S. Kocanova, G. Monteiro Oliveira, J. A. Mitchell, E. Soutoglou, T. L. Lenstra, N. Molina, , T. Sexton

The paper investigates how transcription and loop extrusion interact to influence promoter and enhancer dynamics through live tracking and simulations.

bioRxiv · Apr 25, 2023 · PreprintCell Biology

Complex small-world regulatory networks emerge from the 3D organisation of the human genome

C. A. Brackley, N. Gilbert, D. Michieletto, A. Papantonis, M. C. F. Pereira, P. R. Cook, D. Marenduzzo

This study shows that 3D genome organization leads to complex small-world regulatory networks and stochastic transcription, explaining how GWAS results align with overexpression experiments.

Nature Communications · Oct 1, 2021Peer-reviewedBiophysics

Cilium induction triggers differentiation of glioma stem cells

G. Goranci-Buzhala, A. Mariappan, L. Ricci-Vitiani, N. Josipovic, S. Pacion, M. Gottardo, J. Ptok, G. C. Callaini, K. Rajalingam, B. Dynlacht, K. Hadian, A. Papantonis, R. Pallini, J. Gopalakrishnan

This study shows that inducing ciliogenesis in glioma stem cells (GSCs) promotes their differentiation and prevents brain infiltration, suggesting cilium induction as a therapeutic strategy for glioblastoma.

bioRxiv · Dec 23, 2020Cell Biology

Genomic instability is an early event driving chromatin reorganization and escape from oncogene-induced senescence

C. Zampetidis, P. Galanos, A. Angelopoulou, Y. Zhu, T. Karamitros, N. Lagopati, R. Mirzazadeh, A. Polyzos, S. Garnerone, E. G. Gusmao, K. Sofiadis, D. E. Pefani, M. Demaria, N. Crosetto, A. Maya-Mendoza, , V. G. Gorgoulis

The paper identifies an early chromosomal inversion that enables escape from oncogene-induced senescence by activating BHLHE40 and promoting malignant transformation.

bioRxiv · Dec 20, 2020Cell Biology

Redundant and specific roles of cohesin STAG subunits in chromatin looping and transcription control

V. Casa, M. Moronta Gines, E. Gade Gusmao, J. A. Slotman, A. Zirkel, N. Josipovic, E. Oole, W. F. J. van IJcken, A. B. Houtsmuller, A. Papantonis, K. S. Wendt

This study investigates the roles of SA1 and SA2 cohesin subunits in chromatin looping and transcription control using HCT116 cells and human neural stem cells.

Genome Research · Apr 6, 2020Peer-reviewedCell Biology

Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology

Y. Kargapolova, R. Rehimi, H. Kayserli, J. Bruehl, A. Zirkel, Y. Li, G. Yigit, A. Hoischen, S. Frank, N. Russ, J. Trautwein, M. Laugsch, E. G. Gusmao, N. Josipovic, J. Altmeuller, , A. Papantonis

The paper identifies a CHD6 mutation causing Hallermann-Streiff syndrome and shows it disrupts autophagy and DNA damage response through chromatin remodeling.

bioRxiv · Jan 27, 2020Cell Biology

Spatial chromosome folding and active transcription drive DNA fragility and formation of oncogenic MLL translocations

H. J. Gothe, B. A. M. Bouwman, E. G. Gusmao, R. Piccinno, S. Sayols, O. Drechsel, G. Petrosino, V. Minneker, N. Josipovic, A. Mizi, C. F. Nielsen, E.-M. Wagner, S. Takeda, H. Sasanuma, D. F. Hudson, , V. Roukos

The paper shows that transcription and spatial chromosome folding increase DNA fragility, leading to oncogenic translocations in leukemia.

bioRxiv · Dec 3, 2018Cell Biology

Shaping Epigenetic Memory via Genomic Bookmarking

D. Michieletto, M. Chiang, D. Coli, A. Papantonis, E. Orlandini, P. R. Cook, D. Marenduzzo

This paper introduces a biophysical model of genomic bookmarking to explain how epigenetic domains are maintained and modified through histone marks and protein interactions in Drosophila.

bioRxiv · Nov 20, 2017Biophysics