Author

E. Hirsch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Bourcier· 1 shared A. Ghigo· 1 shared A. Gomez-Brouchet· 1 shared A. Hivonnait· 1 shared A. Varin· 1 shared B. Garmy-Susini· 1 shared B. Thibault· 1 shared C. Campa· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperPhysiology

A. Bourcier

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cardiac gene therapy with PDE2A limits remodeling and arrhythmias in mouse models of heart failure induced by catecholamines

R. Kamel, A. Bourcier, J. P. Margaria, A. Varin, A. Hivonnait, F. Mercier-Nome, D. Mika, A. Ghigo, F. Charpentier, V. Algalarrondo, E. Hirsch, R. Fischmeister, G. Vandecasteele, J. Leroy

bioRxiv · Apr 17, 2023 · PreprintPhysiology

Phosphoproteomics identifies PI3K inhibitor-selective adaptive responses in pancreatic cancer cell therapy and resistance

C. Cintas, T. Douche, Z. Dantes, E. Mouton-Barbosa, M.-P. Bousquet, C. Cayron, N. Therville, F. Pont, F. Ramos-Delgado, C. Guyon, B. Garmy-Susini, P. Cappello, O. Burlet-Schiltz, E. Hirsch, A. Gomez-Brouchet, , J. Guillermet-Guibert

This study identifies adaptive phosphoprotein responses to isoform-selective PI3K inhibitors in pancreatic cancer, showing that combination therapy can overcome resistance.

bioRxiv · Oct 8, 2020Cancer Biology

Activation of Rab11a and endocytosis by Phosphatidylinositol 4-kinase III beta promotes oncogenic signaling in breast cancer

S. MacDonald, K. Harding, P. Bilodeau, C. de Souza, C. Campa, E. Hirsch, R. Auer, J. Lee

This study shows that PI4KIIIβ promotes breast cancer by regulating endocytic kinetics and Rab11a-mediated signaling through its interaction with Rab11a, independent of its kinase activity.

bioRxiv · Feb 10, 2020 · PreprintCancer Biology