T. Douche

Biogenesis of DNA-carrying extracellular vesicles by the dominant human gut methanogenic archaeon

This study characterizes DNA-carrying extracellular vesicles (EVs) from Methanobrevibacter smithii, revealing their role in DNA and protein export in the gut.

In-host evolution of Yersinia enterocolitica during a chronic human infection

This study tracks genetic and phenotypic changes in Yersinia enterocolitica during a chronic human infection, revealing host-adaptive mutations and antibiotic resistance mechanisms.

A multi-year longitudinal harmonization of quality controls in mass spectrometry proteomics core facilities

This study harmonizes quality controls across proteomics core facilities to improve data comparability and reliability through a 4-year longitudinal dataset and common processing software.

The RBPome of influenza A virus mRNA reveals a role for TDP-43 in viral replication

The paper identifies RBPs associated with influenza A virus NP mRNA and shows TDP-43's role in viral replication through mRNA binding and polymerase interactions.

Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming

This study shows that senescence promotes reprogramming through the SASP factor Amphiregulin, which enhances proliferation and MET via EGFR signaling, improving reprogramming efficiency.

Acetylation regulates the oligomerization state and activity of RNase J, the major ribonuclease of Helicobacter pylori

This study identifies acetylation of RNase J in H. pylori as a regulatory mechanism that modulates its oligomerization state and enzymatic activity.

Experimental evolution reveals post-transcriptional regulation as a novel driver of Leishmania fitness gain

This study shows that post-transcriptional regulation, not just genome instability, drives fitness gain in Leishmania parasites during in vitro adaptation.

Ser/Thr kinase-dependent phosphorylation of the peptidoglycan hydrolase CwlA controls its export and modulates cell division in Clostridioides difficile

This study identifies CwlA as a substrate of the STK PrkC in C. difficile, showing that phosphorylation regulates its export and modulates cell division by controlling peptidoglycan hydrolysis.

Phosphoproteomics identifies PI3K inhibitor-selective adaptive responses in pancreatic cancer cell therapy and resistance

This study identifies adaptive phosphoprotein responses to isoform-selective PI3K inhibitors in pancreatic cancer, showing that combination therapy can overcome resistance.

Proteomic Analysis Uncovers Measles Virus Protein C Interaction with p65/iASPP/p53 Protein Complex

The paper identifies p65/iASPP/p53 protein complex as a specific interaction partner of measles virus protein C, revealing its role in regulating cell death and innate immunity pathways.

The Flemmingsome reveals an ESCRT-to-membrane coupling required for completion of cytokinesis

The paper identifies a plasma membrane-to-ESCRT module essential for abscission, showing its role in cytokinesis, exosome formation, and HIV budding.