Author

B. Thibault

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

J. Guillermet-Guibert· 4 shared C. Basset· 3 shared C. Cayron· 3 shared N. Therville· 3 shared A. Carrier· 2 shared A. V. Villard· 2 shared C. Cintas· 2 shared F. Pont· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

J. Guillermet-Guibert

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Meat enriched-diet and inflammation promote PI3Kα-dependent pancreatic cell plasticity that limit tissue regeneration.

C. Cayron, D. Bozoglou, A. V. Villard, G. Reyes-Castellanos, N. Therville, R. Baer, S. Arcucci, N. Naud, M. Tosolini, F. Pont, D. Ferreira Da Mota, F. Gueraud, C. Basset, A. Carrier, F. Pierre, , J. Guillermet-Guibert

This study shows that meat-enriched diets and inflammation promote pancreatic cell plasticity via PI3Kα, which limits tissue regeneration and increases cancer risk.

bioRxiv · Aug 22, 2023 · PreprintPathology

The lipid kinase PI3Kα is required for the cohesion and survival of cancer cells disseminated in serous cavities.

B. Thibault, A. Thole, C. Basset, J. Guillermet-Guibert

This study shows that PI3Kα is essential for the cohesion and survival of cancer cells in serous cavities, suggesting it as a therapeutic target.

bioRxiv · Oct 1, 2021 · PreprintCancer Biology

Phosphoproteomics identifies PI3K inhibitor-selective adaptive responses in pancreatic cancer cell therapy and resistance

C. Cintas, T. Douche, Z. Dantes, E. Mouton-Barbosa, M.-P. Bousquet, C. Cayron, N. Therville, F. Pont, F. Ramos-Delgado, C. Guyon, B. Garmy-Susini, P. Cappello, O. Burlet-Schiltz, E. Hirsch, A. Gomez-Brouchet, , J. Guillermet-Guibert

This study identifies adaptive phosphoprotein responses to isoform-selective PI3K inhibitors in pancreatic cancer, showing that combination therapy can overcome resistance.

bioRxiv · Oct 8, 2020Cancer Biology

Pancreatic Cancer Intrinsic PI3Kα Activity accelerates Metastasis and rewires Macrophage Component

B. Thibault, F. Ramos-Delgado, E. Pons-Tostivint, N. Therville, C. Cintas, S. Arcucci, S. Cassant-Sourdy, G. Reyes-Castellanos, M. Tosolini, A. V. Villard, C. Cayron, R. Baer, J. Bertrand-Michel, D. Payen, H. Yan, , J. Guillermet-Guibert

This paper identifies PI3K pathway activation as a driver of metastatic progression in pancreatic cancer and shows that targeting PI3K can delay macro-metastatic evolution.

bioRxiv · Sep 23, 2020Cancer Biology

Mesenchymal stromal cells release CXCL1/2/8 and induce chemoresistance and macrophage polarization

B. Couderc, A. Le Naour, M. Prat, R. Mevel, B. Thibault, L. Lemaitre, H. Leray, M. Golzio, L. Lefevre, E. Mery, A. Martinez, G. Ferron, J.-P. Delord, A. Coste

This study identifies CXCL1/2/8 as factors released by cancer-associated mesenchymal stromal cells that induce chemoresistance and macrophage polarization, suggesting CXCR1/2 inhibition as a potential therapeutic strategy.

bioRxiv · Dec 4, 2018 · PreprintCancer Biology