Immunogenicity, safety and efficacy of sequential immunizations with an SIV-based IDLV expressing CH505 Envs
M. Blasi, D. Negri, K. O. Saunders, E. J. Baker, H. Stadtler, C. LaBranche, B. Mildenberg, G. Morton, A. Ciarla, X. Shen, Y. Wang, W. Rountree, B. Balakumaran, S. Santra, B. F. Haynes, , M. E. Klotman
This study evaluates an SIV-based IDLV vaccine expressing sequential CH505 Envs in rhesus macaques, showing improved antibody responses and virus control but no broadly neutralizing antibodies.
bioRxiv · Mar 6, 2020Immunology