ImmunologybioRxiv
Persistent Immunogenicity of Integrase Defective Lentiviral Vectors delivering membrane tethered Native-Like HIV-1 Envelope Trimers
A. Gallinaro, M. F. Pirillo, Y. Aldon…·A. Cara
This study shows that IDLV vectors with membrane-tethered native-like HIV-1 Env trimers induce faster and longer-lasting anti-Env IgG responses in mice and macaques, with some animals developing neutralization activity against HIV-1.
DOI 10.1038/s41541-022-00465-1