A. Camilli

Identifying essential genes in Schaalia odontolytica using a highly-saturated transposon library

This study identifies essential genes in Schaalia odontolytica using high-throughput transposon insertion sequencing.

RNA interactome of hypervirulent Klebsiella pneumoniae reveals a small RNA inhibitor of capsular mucoviscosity and virulence

This study identifies ArcZ as a small RNA inhibitor of capsular hypermucoviscosity and virulence in hypervirulent Klebsiella pneumoniae through RNA interactome profiling.

A Vibrio cholerae Anti-Phage System Depletes Nicotinamide Adenine Dinucleotide to Restrict Virulent Bacteriophages

The paper identifies a Vibrio cholerae anti-phage system, Nezha, that depletes NAD+ to restrict virulent phages, with a phage counteracting this by regenerating NAD+.

Streptococcus pneumoniae infection of lung epithelial cells induces internalization of surface GPI-anchored proteins through pneumolysin-mediated activation of host Rho GTPases

This study shows that pneumolysin from Streptococcus pneumoniae causes internalization of GPI-anchored proteins in lung epithelial cells via Rho GTPase activation, reducing cell death and membrane damage.

Development of a monoclonal antibody to a vibriophage as a proxy for Vibrio cholerae detection

This study develops a monoclonal antibody to the vibriophage ICP1 to improve cholera detection in rapid diagnostic tests by detecting the phage as a proxy for Vibrio cholerae.

Bile Salts and N-Acetyl-D-Glucosamine induce transcription of the vieSAB Operon in Vibrio cholerae El Tor

This study identifies bile salts and N-acetyl-D-glucosamine as inducers of the vieSAB operon in El Tor biotype V. cholerae, revealing its role in adapting to the human host.

A genetic interaction screen in Streptococcus pneumoniae identifies functionally redundant vaccine candidate proteins CbpC and CbpJ

The paper identifies functionally redundant surface proteins CbpC and CbpJ in S. pneumoniae as potential bivalent vaccine candidates through a genetic interaction screen.

A Tail Fiber Protein and a Receptor-Binding Protein Mediate ICP2 Bacteriophage Interactions with Vibrio cholerae OmpU

This study identifies ICP2 phage proteins involved in binding to V. cholerae OmpU and shows that mutations in gp25 and gp23 are required for host-range adaptation.

A Tn-seq screen of Streptococcus pneumoniae uncovers DNA repair as the major pathway for desiccation tolerance and transmission

This study uses Tn-seq to identify DNA repair pathways critical for desiccation tolerance and transmission of Streptococcus pneumoniae.

Prophage-dependent neighbor predation fosters horizontal gene transfer by natural transformation

The paper shows that prophage-dependent neighbor predation in Vibrio cholerae enhances horizontal gene transfer via natural transformation in chitin estuary microcosms.

The generation of persister cells is regulated at the initiation of translation by (p)ppGpp

This study shows that (p)ppGpp regulates persister cell generation in UPEC by controlling translation initiation, leading to antibiotic tolerance.

Identification of spacer and protospacer sequence requirements in the Vibrio cholerae Type I-E CRISPR/Cas System

This study identifies sequence requirements for CRISPR/Cas immunity in Vibrio cholerae, showing that a 5-RTT-3 PAM is necessary for spacer acquisition and interference.

Niche adaptation limits bacteriophage predation of Vibrio cholerae in a nutrient-poor aquatic environment

This study shows that virulent phages have varying abilities to infect Vibrio cholerae in nutrient-poor aquatic environments, with ICP1 being the only effective predator in estuarine water.