Targeting metabolic adaptations in the breast cancer liver metastatic niche using dietary approaches to improve endocrine therapy efficacy
Q. Zuo, A. N. Mogol, Y.-J. Liu, A. S. Casiano, C. Chien, J. Drnevich, O. B. Imir, E. Kulkoyluoglu-Cotul, N. H. Park, D. J. Shapiro, B. H. Park, Y. Ziegler, B. S. Katzenellenbogen, E. Aranda, J. D. O'Neill, , Z. Madak-Erdogan
This study identifies a mechanism of endocrine resistance in liver metastases of ER+ breast cancer and shows that a fasting-mimicking diet enhances the efficacy of fulvestrant treatment.
bioRxiv · Sep 7, 2021Cancer Biology