Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection
M. A. Duque-Correa, N. A. Karp, C. McCarthy, S. Forman, D. Goulding, G. Sankaranarayanan, T. P. Jenkins, A. J. Reid, H. P. Browne, E. L. Cambridge, C. Ballesteros Reviriego, W. Müller, C. Cantacessi, G. Dougan, R. K. Grencis, , The 3i consortium
This study shows that IL-10R signaling in immune cells is essential for controlling whipworm infection, microbiota homeostasis, and preventing immunopathology in mice.
bioRxiv · Aug 8, 2018Immunology