C. McCarthy

Iron deficiency in people with obesity drives defective natural killer cell mitochondrial fitness and function

This study shows that iron deficiency in people with obesity impairs NK cell mitochondrial function and cytokine production.

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

Several independent adaptations of archaea to hypersaline environments

This study resolves the phylogeny of extremely halophilic archaea and identifies four independent adaptations to hypersaline environments through phylogenomic analysis and gene transfer mechanisms.

A drug repurposing screen for whipworms informed by comparative genomics

This paper identifies potential anti-whipworm drugs by testing approved human drugs ex vivo and in vivo, finding limited efficacy due to pharmacokinetic challenges.

IL-1β turnover by TRIP12 and AREL1 ubiquitin ligases and UBE2L3 limits inflammation

This study identifies UBE2L3, TRIP12, and AREL1 as ubiquitin ligases that regulate pro-IL-1β turnover, limiting inflammation by reducing precursor availability.

Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction

The paper shows that mucolytic bacteria enable pathobionts to acquire host-derived nutrients during dietary restriction, allowing them to thrive in the gut.

Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer

This study characterizes clinical and molecular features of acquired resistance to PD-(L)1 blockade in NSCLC, identifying persistent inflammation and dysfunctional IFN signaling as key features.

Defining the early stages of intestinal colonisation by whipworms

This study investigates whipworm invasion of the intestinal epithelium using mouse models and single-cell RNA sequencing, revealing host-parasite interactions and immune responses.

Differentiation of Human Colon Tissue In Culture: Effects of calcium on trans-epithelial electrical resistance and tissue cohesive properties

This study examines how calcium levels affect colonoid tissue barrier function and cohesion, finding that low calcium supports permeability barriers while higher levels enhance tissue cohesion.

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

This study shows that IL-10R signaling in immune cells is essential for controlling whipworm infection, microbiota homeostasis, and preventing immunopathology in mice.