R. K. Grencis

This study identifies A20 as an essential myeloid factor for inducing type-2 immune responses against Trichuris muris, with its loss leading to chronic infection and inflammation.

This study shows that mucin-degrading gut bacteria influence anti-parasitic immunity by modulating host immune responses, with dietary fiber affecting this interaction.

This study shows diurnal rhythms in intestinal IgA regulate oscillations in commensal microbiota abundance, promoting mutualism.

This study shows that sustained T-bet expression is necessary for maintaining intestinal ILC1 in vivo, and ILC1 depletion protects against colitis, suggesting potential therapeutic targeting of T-bet for IBD treatment.

This study shows that SLC7A5-mediated mTOR activation in CD4+ T cells is essential for effective Type 2 immunity and resistance to T. muris infection.

This study investigates whipworm invasion of the intestinal epithelium using mouse models and single-cell RNA sequencing, revealing host-parasite interactions and immune responses.

This paper develops a caecal organoid model to study host-pathogen interactions, revealing immunoregulatory effects of Trichuris muris extracellular vesicles on caecal epithelium.

This study shows IL-17A suppresses IFNγ to initiate and later limits type-2 immune responses in the lung during nematode infection.

This study shows that repeated low-dose infection with Trichuris muris leads to gradual immunity, with CD4+ T cells playing a key role, and alters gut microbiota.

This study shows that IL-10R signaling in immune cells is essential for controlling whipworm infection, microbiota homeostasis, and preventing immunopathology in mice.