D. Goulding

An invariant Trypanosoma vivax vaccine antigen inducing protective immunity

This study identifies an invariant Trypanosoma vivax antigen that induces protective immunity through vaccination and monoclonal antibodies.

Host adaptation in gut Firmicutes is associated with sporulation loss and altered colonisation patterns

The paper shows that loss of sporulation in gut Firmicutes is linked to host adaptation, with non-sporulating bacteria being more abundant but less prevalent globally.

Defining the early stages of intestinal colonisation by whipworms

This study investigates whipworm invasion of the intestinal epithelium using mouse models and single-cell RNA sequencing, revealing host-parasite interactions and immune responses.

Development of caecaloids to study host-pathogen interactions: new insights into immunoregulatory functions of Trichuris muris extracellular vesicles in the caecum

This paper develops a caecal organoid model to study host-pathogen interactions, revealing immunoregulatory effects of Trichuris muris extracellular vesicles on caecal epithelium.

The capsule regulatory network of Klebsiella pneumoniae defined by density-TraDISort

This study identifies genes regulating capsule production in K. pneumoniae using density-TraDISort, revealing a complex regulatory network involving multiple global regulators.

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

This study shows that IL-10R signaling in immune cells is essential for controlling whipworm infection, microbiota homeostasis, and preventing immunopathology in mice.