Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
Q. Wang, J. Hsiao, N. Yardeny…·D. A. Bachovchin
This study identifies chemical probes that induce reductive stress and shows that reductive stress and peptide accumulation together strongly activate NLRP1 and CARD8 inflammasomes.
J. C. Hsiao, A. R. Neugroschl, A. J. Chui…·D. A. Bachovchin
This study identifies a ubiquitin-independent proteasome pathway that degrades the CARD8 N-terminal fragment, releasing the inflammatory C-terminal fragment and activating the inflammasome.
E. L. Orth-He, H.-C. Huang, S. D. Rao…·D. A. Bachovchin
This study identifies cytosolic peptide accumulation as a danger signal that activates NLRP1 and CARD8 inflammasomes by promoting NT degradation and disrupting DPP9-mediated sequestration of CT fragments.