Fatty Acid Synthase inhibitor TVB-3166 prevents S-acylation of the Spike protein of human coronaviruses.
K. Mekhail, M. Lee, M. Sugiyama, A. Astori, J. St-Germain, E. Latreille, N. Khosraviani, K. Wei, W. L. Lee, C. N. Antonescu, B. Raught, G. D. Fairn
This study shows that TVB-3166 inhibits S-acylation of coronavirus Spike proteins, reducing viral spread and improving survival in mice.
Journal of Lipid Research · Sep 1, 2022Peer-reviewedCell Biology