B. Raught

Cryo-EM of AKAP350 reveals fibrillar clusters and a potential association with DNA

This study uses cryo-EM to show AKAP350 forms fibrillar clusters and interacts with DNA and DNA-binding proteins like NFIB and NCL.

The co-chaperone DNAJA2 buffers proteasomal degradation of cytosolic proteins with missense mutations

The paper identifies cytosolic mutant proteins degraded by the proteasome and shows DNAJA2 stabilizes some mutants while being dispensable for wild-type proteins.

Adenomatous polyposis coli (APC) regulates internalization and signaling of the chemorepellent receptor, Roundabout (ROBO) 1

This study identifies APC's role in SLIT2-induced ROBO1 endocytosis and its impact on cell morphology.

Recruitment of FBXO22 for Targeted Degradation of NSD2

This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

This study identifies mitochondrial calcium utilization as a metabolic requirement of venetoclax-resistant acute myeloid leukemia stem cells and shows that targeting mitochondrial calcium uptake can eradicate these cells.

The maintenance of centriole appendages and motile cilia basal body anchoring relies on TBCCD1

This study identifies TBCCD1 as essential for centriole appendage assembly and maintenance, and for anchoring motile cilia basal bodies, with implications for ciliopathy networks.

PRMT1 is a critical dependency in clear cell renal cell carcinoma through its role in post-transcriptional regulation of DNA damage response genes

GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program

This study identifies distinct interactions of GEMC1 and MCIDAS with SWI/SNF subcomplexes in multiciliated cell differentiation and shows that these interactions are required for MCC-specific transcriptional regulation.

Aberrant DNA repair is a vulnerability in histone H3.3-mutant brain tumors

The paper identifies aberrant DNA repair as a vulnerability in H3.3-mutant brain tumors, showing that PNKP-mediated repair is specific to mutant cells and offers therapeutic potential.

Fatty Acid Synthase inhibitor TVB-3166 prevents S-acylation of the Spike protein of human coronaviruses.

This study shows that TVB-3166 inhibits S-acylation of coronavirus Spike proteins, reducing viral spread and improving survival in mice.

SUMOylation of ABCD3 restricts bile acid synthesis and regulates metabolic homeostasis

This study identifies MAPL's role in regulating bile acid synthesis and metabolic homeostasis, showing its loss leads to insulin sensitivity and hepatocellular carcinoma.

A SARS-CoV-2 BioID-based virus-host membrane protein interactome and virus peptide compendium: new proteomics resources for COVID-19 research

The paper uses BioID and mass spectrometry to identify SARS-CoV-2-host membrane protein interactions and virus peptides, providing new proteomics resources for COVID-19 research.

Nucleotide binding, evolutionary insights and interaction partners of the pseudokinase Unc-51-like kinase 4

This study presents the structure of ULK4-ATPγS complex, identifies disease mutations affecting ATP binding, and reveals ULK4's interaction partners and evolutionary adaptations.

LUZP1 and the tumour suppressor EPLIN are negative regulators of primary cilia formation

This study identifies LUZP1 and EPLIN as negative regulators of primary cilia formation by modulating actin dynamics at the centrosome and basal body.

Super-resolution Molecular Map of Basal Foot Reveals Novel Cilium in Airway Multiciliated Cells

The paper uses super-resolution imaging to reveal a novel hybrid cilium in airway multiciliated cells and its role as a signaling center.

Endogenous BioID elucidates TCF7L1 interactome modulation upon GSK-3 inhibition in mouse ESCs

The paper uses BioID to study TCF7L1 interactome changes in mouse ESCs with GSK-3 inhibition, identifying new interactors and showing increased detection with reduced BirA*-TCF7L1 levels.