K. Wei

Distinct tissue-niche localization and function of synovial tissue myeloid DC subsets in health, and in active and remission Rheumatoid Arthritis

This study identifies distinct myeloid DC subsets in synovial tissue across health and RA states, showing their roles in inflammation and tolerance.

Systematic benchmarking of imaging spatial transcriptomics platforms in FFPE tissues

This study benchmarks three imaging spatial transcriptomics platforms on FFPE tissues, finding 10x Xenium has higher transcript counts without sacrificing specificity, while all platforms align with RNA-seq data but vary in performance metrics.

Enhanced neutralization of SARS-CoV-2 XBB sub-lineages and BA.2.86 by a tetravalent COVID-19 vaccine booster

This study evaluates the neutralization efficacy of a tetravalent vaccine booster against emerging SARS-CoV-2 variants, finding it induces higher neutralizing titers than breakthrough infection.

Copy number variation shapes structural genomic diversity associated with ecological adaptation in the wild tomato Solanum chilense

This study identifies CNVs in wild tomato Solanum chilense linked to ecological adaptation, showing gene loss and gain associated with stress response and climate variables.

Adipocytes regulate fibroblast function, and their loss contributes to fibroblast dysfunction in inflammatory diseases

The paper shows adipocytes regulate fibroblast function through cortisol signaling, and their loss leads to fibroblast dysfunction in inflammatory diseases.

The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis

The paper identifies chromatin classes in RA synovial tissue and links them to transcriptional cell states and genetic variants.

Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium

This study uses single-cell antigen receptor profiling to identify clonal relationships and functional states of T and B cells in RA synovium.

Targeting fungal BET bromodomains as a pan-Candida antifungal strategy

This study identifies a phenyltriazine compound that selectively targets both Bdf1 bromodomains in Candida species, showing antifungal activity against multiple Candida strains including resistant isolates.

Evolution of two gene networks underlying adaptation to drought stress in the wild tomato Solanum chilense

The paper studies the evolution of two gene networks in Solanum chilense under drought stress, finding that the metabolic network is younger and under recent selection, while the cell-cycle network is ancient and conserved.

Fatty Acid Synthase inhibitor TVB-3166 prevents S-acylation of the Spike protein of human coronaviruses.

This study shows that TVB-3166 inhibits S-acylation of coronavirus Spike proteins, reducing viral spread and improving survival in mice.

Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-COV-2 Delta Variant

This study develops a stable and safe mRNA vaccine (cmRNA-1130) using degradable lipid nanoparticles against the SARS-CoV-2 Delta variant, showing potent immune responses and stability.

Local adaptation to novel habitats and climatic changes in a wild tomato species via selective sweeps.

The paper identifies selective sweeps in Solanum chilense populations linked to adaptation to different altitudes and climates.

Dynamics and impacts of transposable element proliferation during the Drosophila nasuta species group radiation

This study analyzes TE proliferation in seven Drosophila species, finding associations between TE insertion frequency, gene expression, and evolutionary dynamics.

Neo-sex chromosome evolution shapes sex-dependent asymmetrical introgression barrier

This study examines how neo-sex chromosome evolution creates sex-dependent asymmetrical introgression barriers in a hybrid swarm of Drosophila species.

Arthritis Flares Mediated by Tissue Resident Memory T Cells in the Joint

This study identifies synovial tissue-resident memory T cells as mediators of arthritis flares in murine models and finds a comparable population in human rheumatoid arthritis tissues.

IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel disease

Steric Regulation of Tandem Calponin Homology Domain Actin-Binding Affinity

The paper investigates how structural modifications affect the actin-binding affinity of tandem CH1-CH2 domains, finding that steric changes and interface mutations influence binding properties and sub-cellular localization.

HBEGF+ macrophages identified in rheumatoid arthritis promote joint tissue invasiveness and are reshaped differentially by medications

A newly identified human macrophage phenotype in RA promotes joint tissue invasiveness and shows variable responses to anti-inflammatory medications.

Pathologically distinct fibroblast subsets drive inflammation and tissue damage in arthritis

The paper identifies two distinct fibroblast subsets in arthritis that drive inflammation or tissue damage, showing their unique roles in disease progression.

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry

The paper identifies key inflammatory cell states in RA synovial tissues using integrated single-cell and mass cytometry data from patient samples.

High dimensional analyses of cells dissociated from cryopreserved synovial tissue

This paper establishes a protocol for dissociating cryopreserved synovial tissue to obtain viable cells with preserved transcriptomes and surface markers, enabling high-dimensional analysis of rheumatoid arthritis pathology.

Single Cell Transcriptomics And Flow Cytometry Reveal Disease-Associated Fibroblast Subsets In Rheumatoid Arthritis

The paper identifies disease-associated fibroblast subsets in rheumatoid arthritis using single-cell transcriptomics and flow cytometry, revealing subset-specific markers and functional differences.