The catheterized bladder environment induces dysregulation of macrophage polarization exacerbating bacterial UTI
A. M. Marrufo, J. J. Molina, C. Gager, M. J. Andersen, A. A. La Bella, E. Lucas, E. Wongso, T. Urmi, K. Arias-Parbul, R. Webster, P. V. Stuckey, K. N. Kohler, D. Donahue, V. Ploplis, M. J. Flick, , A. L. Flores-Mireles
This study shows that fibrin accumulation in a catheterized bladder promotes anti-inflammatory macrophage polarization, which impairs antimicrobial responses and allows bacterial persistence in UTIs.
bioRxiv · Jul 16, 2024 · PreprintImmunology