Cell size homeostasis is maintained by a circuitry involving a CDK4-determined target size that programs the cell size-dependent activation of p38
C. Tan, M. B. Ginzberg, R. Webster, S. Iyengar, J. Concannon, Y. Wang, D. S. Auld, J. L. Jenkins, H. Rost, A. Hilfinger, B. Derry, N. Patel, R. Kafri
The paper identifies CDK4 as a regulator of cell size target size, distinct from growth-promoting pathways, and proposes a model linking mTORC1, p38, and CDK4 in cell size homeostasis.
bioRxiv · Oct 14, 2020Cell Biology