Evolutionary BiologybioRxiv
A computational method for predicting the most likely evolutionary trajectories in the stepwise accumulation of resistance mutations
R. C. Eccleston, E. Manko, S. Campino…·N. Furnham
The paper predicts evolutionary trajectories of drug resistance mutations using a computational model parameterized by binding affinity, showing agreement with experimental and isolate data.
DOI 10.7554/elife.84756