The finger 2 tip loop of Activin A is required for the formation of its non-signaling complex with ACVR1 and type II Bone Morphogenetic Protein receptors
S. Aykul, R. A. Corpina, E. J. Goebel, C. J. Cunanan, A. Dimitriou, H. Kim, Q. Zhang, A. Rafique, R. Leidich, X. Wang, J. McClain, J. Jimenez, K. C. Nannuru, N. J. Rothman, J. B. Lees-Shepard, , V. Idone
The paper shows that the non-signaling complex formed by Activin A and ACVR1 reduces disease severity in FOP by tempering heterotopic ossification.
bioRxiv · May 28, 2020 · PreprintCell Biology