Author

A. Rafique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:differential expression· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Baum· 2 shared A. J. Murphy· 2 shared K. E. Pascal· 2 shared X. Wang· 2 shared A. Barve· 1 shared A. Dauphin· 1 shared A. Dimitriou· 1 shared A. N. Economides· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

A. Baum

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structure of the Inmazeb cocktail and resistance to escape against Ebola virus

V. Rayaprolu, B. Fulton, A. Rafique, E. Arturo, D. Williams, C. Hariharan, H. Callaway, A. Parvate, S. L. Schendel, D. Parekh, S. Hui, K. Shaffer, K. E. Pascal, E. Wloga, S. Giordano, , E. O. Saphire

The paper presents the cryoEM structure of the Inmazeb cocktail in complex with Ebola virus glycoprotein, showing how the combination prevents escape mutations better than monotherapy.

bioRxiv · Oct 11, 2022Biophysics

Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM

K. Saotome, D. Dudgeon, K. Colotti, M. J. Moore, J. Jones, Y. Zhou, A. Rafique, G. D. Yancopoulos, A. J. Murphy, J. C. Lin, W. C. Olson, M. C. Franklin

The paper reports cryoEM structures of TCR-CD3 complexes and pMHC ligands, revealing structural insights into TCR recognition of cancer antigens.

bioRxiv · Aug 18, 2022Biochemistry

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

L. Yurkovetskiy, X. Wang, K. E. Pascal, C. Tompkins-Tinch, T. Nyalile, Y. Wang, A. Baum, W. E. Diehl, A. Dauphin, C. Carbone, K. Veinotte, S. B. Egri, S. F. Schaffner, J. E. Lemieux, J. Munro, , J. Luban

This study shows the D614G SARS-CoV-2 spike protein variant is more infectious but has reduced ACE2 affinity and altered trimer conformation, affecting viral entry and antibody neutralization.

bioRxiv · Jul 4, 2020Microbiology

The finger 2 tip loop of Activin A is required for the formation of its non-signaling complex with ACVR1 and type II Bone Morphogenetic Protein receptors

S. Aykul, R. A. Corpina, E. J. Goebel, C. J. Cunanan, A. Dimitriou, H. Kim, Q. Zhang, A. Rafique, R. Leidich, X. Wang, J. McClain, J. Jimenez, K. C. Nannuru, N. J. Rothman, J. B. Lees-Shepard, , V. Idone

The paper shows that the non-signaling complex formed by Activin A and ACVR1 reduces disease severity in FOP by tempering heterotopic ossification.

bioRxiv · May 28, 2020 · PreprintCell Biology