NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4
P. Jain, A. Dvorkin-Gheva, E. Mollen, M. Xie, F. Jessa, P. Dhavarasa, S. Chung, K. R. Brown, G. H. Jang, F. Notta, J. Moffat, D. Hedley, P. C. Boutros, B. G. Wouters, M. Koritzinsky
This study identifies NOX4 as a link between metabolic deregulation and ER-specific redox vulnerability in PDAC, suggesting PRDX4 as a therapeutic target for pancreatic cancer.
bioRxiv · Oct 8, 2020Cancer Biology