S. Chung

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

This study shows SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids, upregulating interferon signaling linked to cytokine release syndrome.

Responses to membrane potential-modulating ionic solutions measured by magnetic resonance imaging of cultured cells and in vivo rat cortex

This study uses MRI to measure responses of cultured cells and in vivo rat cortex to ionic solutions that modulate membrane potential, finding changes in T2 relaxation time and bound-to-free water proton ratio.

Single-cell and spatial transcriptomics reveals the human liver immunological landscape and myeloid dysfunction in PSC.

This paper uses single-cell and spatial transcriptomics to map the immune landscape of PSC livers, revealing myeloid dysfunction and cytokine-driven inflammation.

Endogenous viral elements constitute a complementary source of antigens for personalized cancer vaccines

This paper identifies endogenous viral elements as a new source of antigens for personalized cancer vaccines and introduces a computational pipeline to predict and test their therapeutic potential.

Engineered human brown adipocyte microtissues improved glucose and insulin homeostasis in high fat diet-induced obese and diabetic mice

This study develops 3D human brown adipose microtissues that improve glucose and insulin homeostasis in obese and diabetic mice.

Single Cell, Single Nucleus and Spatial RNA Sequencing of the Human Liver Identifies Hepatic Stellate Cell and Cholangiocyte Heterogeneity

This study uses scRNA-seq and snRNA-seq to analyze 73,295 human liver cells, revealing heterogeneity in hepatic stellate cells, cholangiocytes, and interzonal hepatocytes.

NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4

This study identifies NOX4 as a link between metabolic deregulation and ER-specific redox vulnerability in PDAC, suggesting PRDX4 as a therapeutic target for pancreatic cancer.

The C-terminus is critical for the degradation of substrates by the Pseudomonas aeruginosa CtpA protease

This paper shows that CtpA protease requires both C-terminal-dependent cleavage and C-terminal-independent complex association for substrate degradation.

Receptor compaction and GTPase movements drive cotranslational protein translocation

This study shows that SRP-induced compaction of SR and GTPase movements are essential for efficient cotranslational protein translocation at the ER, with implications for disease.

Targeting dual signaling pathways in concert with immune checkpoints for the treatment of pancreatic cancer

This study shows that combining MEK and CDK4/6 inhibitors with immune checkpoint inhibitors improves pancreatic cancer treatment by enhancing T-cell infiltration and altering myeloid populations in preclinical models.

High-throughput smFRET analysis of freely diffusing nucleic acid molecules and associated proteins

This paper introduces a high-throughput smFRET method using multispot excitation and SPAD arrays to rapidly analyze nucleic acid and protein conformations and interactions.

Graphene-oxide quenching-based molecular beacon imaging of exosome-mediated transfer of neurogenic miR-193a on microfluidic platform

The paper develops a molecular beacon imaging method using graphene-oxide quenching to visualize miR-193a transfer via exosomes during neurogenesis on a microfluidic platform.

The effect of macromolecular crowding on single-round transcription by E. coli RNA polymerase

This study investigates how macromolecular crowding affects single-round transcription by E. coli RNA polymerase, finding unexpected enhancements in kinetics with large crowders.

Multispot single-molecule FRET: high-throughput analysis of freely diffusing molecules

The paper introduces a multispot confocal setup for high-throughput smFRET assays and validates its performance using bacterial RNA transcription kinetics.