Author

M. Koritzinsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Dvorkin-Gheva· 1 shared B. G. Wouters· 1 shared D. Hedley· 1 shared E. Mollen· 1 shared F. Jessa· 1 shared F. Notta· 1 shared G. H. Jang· 1 shared J. Moffat· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. Dvorkin-Gheva

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2 papers

Recent·Most cited

Dabrafenib alters MDSC differentiation and function by activation of GCN2

M. T. Ciudad, R. Quevedo, S. Lamorte, R. Jin, N. Nzirorera, M. Koritzinsky, T. L. McGaha

This study shows that dabrafenib inhibits PMN-MDSC differentiation via GCN2 activation, altering their function and reducing their suppressive activity in tumors.

bioRxiv · Aug 9, 2023Immunology

NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4

P. Jain, A. Dvorkin-Gheva, E. Mollen, M. Xie, F. Jessa, P. Dhavarasa, S. Chung, K. R. Brown, G. H. Jang, F. Notta, J. Moffat, D. Hedley, P. C. Boutros, B. G. Wouters, M. Koritzinsky

This study identifies NOX4 as a link between metabolic deregulation and ER-specific redox vulnerability in PDAC, suggesting PRDX4 as a therapeutic target for pancreatic cancer.

bioRxiv · Oct 8, 2020Cancer Biology