P. Jain

Antimicrobial peptides modulate lung injury by altering the intestinal microbiota

The paper shows that antimicrobial peptides (AMPs) in the intestine modulate lung injury by altering the microbiota in response to hyperoxia.

CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival

This study shows that inhibiting CDK12 and CDK13 reduces glioma cell proliferation and migration, and disrupts transcription and cell cycle progression in glioblastoma.

Localized measurements of water potential reveal large loss of conductance in living tissues of maize leaves

The paper measures localized water potential in maize leaf tissues, revealing significant hydraulic conductance loss in the OXZ and its role in regulating transpiration.

Steroid Receptor Coactivator-3 is a Key Modulator of Regulatory T Cell-Mediated Tumor Evasion

This study shows that deleting SRC-3 in regulatory T cells eradicates tumors in mouse models by enhancing antitumor immunity without autoimmune side effects.

Nucleoside-driven specificity of DNA Methyltransferase

The paper studies the adenosine binding specificities of two bacterial DNA methyltransferases, showing differences in cofactor recognition and suggesting a new approach for designing unnatural cofactor analogs.

Transcriptional profiles of functionally distinct HLADR+CD38+ CD8 T cells subsets from acute febrile dengue patients

This study identifies transcriptional differences among HLADR+CD38+ CD8 T cell subsets in dengue patients and shows similar expansion patterns across disease severity grades.

Epigenetic memory acquired during long-term EMTinduction governs the recovery to the epithelial state

The paper shows that long-term EMT induction in MCF10A cells can be reversible with longer timescales, and epigenetic memory via miR-200 silencing by ZEB slows recovery to the epithelial state.

Floral humidity as a signal--not a cue--in a nocturnal pollination system

The paper investigates floral humidity in the Datura wrightii-Manduca sexta pollination system, finding it acts as an attractive signal rather than a reliable cue for nectar presence.

A novel method for producing functionalized vesicles that efficiently deliver oligonucleotides in vitro in cancer cells and in vivo in mice

This paper introduces a novel method for producing functionalized vesicles that deliver oligonucleotides efficiently in vitro and in vivo, showing reduced dialysis time and improved targeting in cancer cells and mice.

Synergistic regulation of bZIP53 and dimerizing partners results in abnormal seed phenotype in Arabidopsis: Use of a designed dominant negative protein A-ZIP53

This study uses a dominant negative protein A-ZIP53 to inhibit bZIP53 and its dimerizing partners in Arabidopsis, revealing their role in seed maturation and plant growth.

The terminal heme synthetic enzyme, Coproheme Decarboxylase, coordinates heme synthesis and uptake in response to iron in Mycobacteria

This study identifies Coproheme Decarboxylase (ChdC) as a regulator of heme synthesis and uptake in Mycobacterium tuberculosis, showing it controls heme bioavailability and iron acquisition in response to iron availability.

NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4

This study identifies NOX4 as a link between metabolic deregulation and ER-specific redox vulnerability in PDAC, suggesting PRDX4 as a therapeutic target for pancreatic cancer.

A multifunctional type IA DNA/RNA topoisomerase with RNA hydrolysis and rRNA processing activities from Mycobacterium smegmatis and Mycobacterium tuberculosis

This study identifies a multifunctional DNA/RNA topoisomerase in mycobacteria that performs RNA hydrolysis and rRNA processing, highlighting its dual catalytic roles in RNA metabolism.

A minimally disruptive method for measuring water potential in-planta using hydrogel nanoreporters

This paper introduces AquaDust, a hydrogel nanoreporter for in situ measurement of leaf water potential in plants, demonstrating its ability to detect water potential gradients and support hydraulic modeling.

Novel BRAF gene fusions in pediatric histiocytic neoplasms define distinct therapeutic responsiveness to RAF paradox breakers

The paper identifies two novel BRAF gene fusions in pediatric histiocytic neoplasms and shows they respond differently to RAF inhibitor therapies due to distinct dimerization mechanisms.

Effect of topical soluble epoxide hydrolase inhibition in a preclinical diabetic wound healing model.

This study tests a topical EPHX2 inhibitor, GSK2256294, in a diabetic wound model, showing improved healing compared to vehicle but not meeting statistical significance.