Author

E. N. Arner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

R. A. Brekken· 2 shared A. Christofides· 1 shared A. E. Bremauntz· 1 shared A. H. Hasty· 1 shared A. Mai· 1 shared A. Rizvi· 1 shared B. I. Reinfeld· 1 shared C. E. Tiron· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

R. A. Brekken

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity

J. E. Bader, M. M. Wolf, M. Z. Madden, B. I. Reinfeld, E. N. Arner, E. S. Hathaway, K. K. Steiner, G. A. Needle, M. D. Landis, M. A. Cottam, X. Ye, A. Christofides, V. A. Boussiotis, S. M. Haake, K. E. Beckermann, , J. C. Rathmell

This study shows obesity induces PD-1 on tumor-associated macrophages, which suppresses anti-tumor immunity by altering metabolic and functional properties of these cells.

bioRxiv · Nov 12, 2022 · PreprintImmunology

AXL-TBK1 driven nuclear AKT3 promotes metastasis

E. N. Arner, J. M. Westcott, S. Hinz, C. E. Tiron, M. Blo, A. Mai, R. Virtakoivu, N. Z. Phinney, S. Nord, K. Y. Aguilera, A. Rizvi, J. E. Toombs, T. Reese, V. Fey, D. Micklem, , R. A. Brekken

This study identifies AXL-TBK1-driven nuclear AKT3 as a driver of EMT and metastasis, showing that selective AKT3 inhibition reduces tumor progression in breast cancer.

bioRxiv · Jan 17, 2022 · PreprintCancer Biology

Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer

V. H. Cruz, E. N. Arner, W. Du, A. E. Bremauntz, R. A. Brekken

This study identifies TBK1 as a key driver of epithelial plasticity in KRAS-mutant pancreatic cancer, showing its role in tumor growth and metastasis through Axl-mediated activation.

bioRxiv · Oct 22, 2018Cancer Biology