A. Rizvi

KipOTIA detoxifies 5-oxoproline and promotes the growth of Clostridioides difficile

This study identifies KipOTIA in C. difficile as a detoxifying enzyme that converts 5-oxoproline into a nutrient, supporting bacterial growth.

Revealing nanoscale structure and interfaces of protein and polymer condensates via cryo-electron microscopy

This study uses cryo-EM to analyze nanoscale structures of protein and polymer condensates, revealing core-shell morphologies and internal inhomogeneities.

Development of a robotic cluster for automated and scalable cell therapy manufacturing

This paper develops a robotic system to automate cell therapy manufacturing, demonstrating comparable results to manual methods in expanding human CD8+ T cells.

Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of lysine demethylation and oxidative phosphorylation

This study shows that heterozygous Kmt2d loss promotes medulloblastoma by enhancing tumor-promoting programs and that combining LSD1 inhibition with oxidative phosphorylation blockade reduces tumorigenicity.

The predicted acetoin dehydrogenase pathway represses sporulation of Clostridioides difficile

This study shows that acetoin and pH regulate sporulation in C. difficile through the aco pathway, with acetoin metabolism not supporting growth as a stationary phase energy source.

Glycine fermentation by C. difficile promotes virulence, spore formation, and is induced by host cathelicidin

This study shows that glycine fermentation by C. difficile enhances virulence, spore formation, and is triggered by host cathelicidin.

AXL-TBK1 driven nuclear AKT3 promotes metastasis

This study identifies AXL-TBK1-driven nuclear AKT3 as a driver of EMT and metastasis, showing that selective AKT3 inhibition reduces tumor progression in breast cancer.

Synaptojanin1 deficiency upregulates basal level autophagosome formation in astrocytes

This study shows Synaptojanin1 deficiency increases basal autophagosome formation in astrocytes, with implications for Parkinsonism.

Structural basis of hypoxic gene regulation by the Rv0081 transcription factor of Mycobacterium tuberculosis

This paper reports the crystal structure of Rv0081, a transcription factor in M. tuberculosis, and identifies key residues involved in hypoxic gene regulation through biochemical analysis.

The miR-96 and RAR&gamma signaling axis governs androgen signaling and prostate cancer progression

This study identifies miR-96 as a regulator of RARγ expression, which in turn controls androgen signaling and prostate cancer progression through gene network alterations.