Qualitative and quantitative top-down proteomics of human colorectal cancer cell lines identified 23000 proteoforms and revealed drastic proteoform-level differences between metastatic and non-metastatic cancer cells
E. N. McCool, T. Xu, W. Chen, N. C. Beller, S. M. Nolan, A. B. Hummon, X. Liu, L. Sun
This study uses top-down proteomics to identify 23,319 proteoforms in colorectal cancer cell lines and finds significant proteoform-level differences between metastatic and non-metastatic cells.
bioRxiv · Oct 27, 2021 · PreprintCancer Biology