Investigation of reversible histone acetylation and dynamics in gene expression regulation using 3D liver spheroid model
S. Stransky, R. Cutler, J. Aguilan, E. Nieves, S. Sidoli
This study shows that 3D liver spheroids can model chromatin dynamics and reversible histone acetylation, with cells recovering their original transcriptome and proteome after histone deacetylase inhibitor treatment.
bioRxiv · Sep 22, 2022Cell Biology