S. Stransky

Histones are exosome membrane proteins regulated by cell stress

This study identifies histones as exosome membrane proteins regulated by cell stress, showing they are secreted via the exosome pathway and lack nuclear post-translational modifications.

Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.

This study shows that H3K36M mutations in HNSCC create a therapeutic window by altering H3K27me3 levels, making tumors sensitive to PARP1/2 inhibitors or their combination with H3K27me3-upregulating agents.

Investigation of reversible histone acetylation and dynamics in gene expression regulation using 3D liver spheroid model

This study shows that 3D liver spheroids can model chromatin dynamics and reversible histone acetylation, with cells recovering their original transcriptome and proteome after histone deacetylase inhibitor treatment.

Epigenetic dysregulation from chromosomal transit in micronuclei

This study shows that chromosomal transit through micronuclei causes epigenetic dysregulation in cancer cells, leading to long-term chromatin accessibility abnormalities.

Genotype-specific Features Reduce the Susceptibility of South American Yellow Fever Virus Strains to Vaccine-Induced Antibodies

This study shows that South American yellow fever virus strains are less susceptible to vaccine-induced antibodies due to genetic changes in the glycoprotein E.

Cytoplasmic labile iron accumulates in aging stem cells perturbing a key rheostat for identity control

This study shows that aging stem cells accumulate labile iron, disrupting a key regulatory pathway that maintains their identity and function.

Quantitative sub-cellular acyl-CoA analysis reveals distinct nuclear regulation

The paper introduces SILEC-SF, a method for sub-cellular metabolomic analysis, and finds distinct nuclear acyl-CoA profiles with notable propionyl-CoA enrichment and a new metabolic pathway for histone propionylation.