The Identification of IL-4 as a Regulator of Chimeric Antigen Receptor T Cell Exhaustion
C. M. Stewart, E. L. Siegler, R. L. Sakemura, M. J. Cox, T. Huynh, B. Kimball, L. Mai, I. Can, C. Manriquez Roman, K. Yun, O. Sirpilla, J. H. Girsch, E. Ogbodo, W. Ismail, A. Gaspar-Maia, , S. S. Kenderian
This study identifies IL-4 as a regulator of CART cell exhaustion and shows that IL-4 neutralization improves antitumor efficacy.
bioRxiv · Sep 28, 2023 · PreprintImmunology