Author

M. J. Cox

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Assay:metagenomics· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

L. Cuthbertson· 3 shared M. F. Moffatt· 3 shared A. James· 2 shared E. M. Turek· 2 shared J. Hui· 2 shared M. Hunter· 2 shared W. O. Cookson· 2 shared A. B. A. Laranjeira· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

L. Cuthbertson

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Multiomic Profiling Reveals Metabolic Alterations Mediating Aberrant Platelet Activity and Inflammation in Myeloproliferative Neoplasms

F. He, A. B. A. Laranjeira, t. kong, A. Liu, K. Bark, N. M. Lasky, D. A. C. Fisher, M. J. Cox, M. Fulbright, L. A. Heck, L. Yu, S. M. Sykes, A. DAlessandro, J. Di Paola, S. Oh

This study identifies metabolic alterations in MPN platelets, showing that alpha-ketoglutarate supplementation reduces hyperreactivity and inflammation.

Journal of Clinical Investigation · Feb 1, 2024Peer-reviewedCancer Biology

The Identification of IL-4 as a Regulator of Chimeric Antigen Receptor T Cell Exhaustion

C. M. Stewart, E. L. Siegler, R. L. Sakemura, M. J. Cox, T. Huynh, B. Kimball, L. Mai, I. Can, C. Manriquez Roman, K. Yun, O. Sirpilla, J. H. Girsch, E. Ogbodo, W. Ismail, A. Gaspar-Maia, , S. S. Kenderian

This study identifies IL-4 as a regulator of CART cell exhaustion and shows that IL-4 neutralization improves antitumor efficacy.

bioRxiv · Sep 28, 2023 · PreprintImmunology

Genomic and ecologic characteristics of the airway microbial-mucosal complex

L. Cuthbertson, U. Lober, J. S. Ish-Horowicz, C. N. McBrien, C. Churchward, J. C. Parker, M. T. Olanipekun, C. Burke, O. O'Carroll, J. Faul, G. A. Davies, K. E. Lewis, J. M. Hopkin, J. Creaser-Thomas, R. Ghosal, , W. O. C. Cookson

The paper characterizes the genomic and ecological features of the airway microbial-mucosal complex, identifying novel bacteria and functional pathways linked to lung diseases.

bioRxiv · Sep 8, 2022 · PreprintMicrobiology

Tales of 1,008 Small Molecules: Phenomic Profiling through Live-cell Imaging in a Panel of Reporter Cell Lines

M. J. Cox, S. Jaensch, J. Van de Waeter, L. Cougnaud, D. Seynaeve, S. Benalla, S. J. Koo, I. Van Den Wyngaert, J.-M. Neefs, D. Malkov, M. Bittremieux, M. Steemans, P. J. Peeters, J. K. Wegner, H. Ceulemans, , H. W. H. Göhlmann

The paper uses live-cell imaging of reporter cell lines to profile 1,008 compounds, identifying their mechanisms of action with high accuracy.

bioRxiv · Mar 13, 2020Pharmacology & Toxicology

Distinctive airway microbial ecology of smokers and asthmatics

E. M. Turek, M. J. Cox, M. Hunter, J. Hui, P. James, S. A. Willis-Owen, L. Cuthbertson, A. James, A. W. Musk, M. F. Moffatt, W. O. Cookson

The paper examines airway microbial communities in smokers and asthmatics, finding smoking reduces diversity and alters bacterial networks, while asthma shows more targeted microbial changes.

bioRxiv · Mar 21, 2019 · PreprintMicrobiology

Haemophilus, antibiotic therapy and the airway microbiome in chronic obstructive pulmonary disease

S. E. Brill, P. L. James, L. Cuthbertson, A. Zhu, T. Lawley, W. O. Cookson, M. J. Cox, J. A. Wedzicha, M. F. Moffatt

This study examines the airway microbiome in COPD patients, finding that Haemophilus influenzae dominance is associated with increased inflammation and that moxifloxacin reduces H. influenzae levels.

bioRxiv · Sep 17, 2018 · PreprintMicrobiology