Author

I. Can

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

C. M. Stewart· 2 shared E. L. Siegler· 2 shared K. Yun· 2 shared R. L. Sakemura· 2 shared S. S. Kenderian· 2 shared A. Alasonyalilar Demirer· 1 shared A. Gaspar-Maia· 1 shared A. Zubair· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

C. M. Stewart

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Optimized CART Cell Therapy for Metastatic Aggressive Thyroid Cancer

C. Manriquez-Roman, E. L. Siegler, J. J. Gleba, T. N. Huynh, G. E. DeFranco, A. Alasonyalilar Demirer, M. L. Pawlush, M. Redig, S. M. Klinge, L. K. Mai, J. L. Miller, E. E. Miller, B. L. Kimball, E. E. Tapper, R. L. Sakemura, , S. S. Kenderian

This paper develops a TSHR-targeted CART cell therapy for thyroid cancer and shows that combining it with MAPK inhibitors improves antitumor efficacy in dedifferentiated thyroid cancers.

bioRxiv · Mar 15, 2024 · PreprintImmunology

The Identification of IL-4 as a Regulator of Chimeric Antigen Receptor T Cell Exhaustion

C. M. Stewart, E. L. Siegler, R. L. Sakemura, M. J. Cox, T. Huynh, B. Kimball, L. Mai, I. Can, C. Manriquez Roman, K. Yun, O. Sirpilla, J. H. Girsch, E. Ogbodo, W. Ismail, A. Gaspar-Maia, , S. S. Kenderian

This study identifies IL-4 as a regulator of CART cell exhaustion and shows that IL-4 neutralization improves antitumor efficacy.

bioRxiv · Sep 28, 2023 · PreprintImmunology